4-Amino-1-methylpiperidine → HCID 25210559, compound

Participants

Reaction Steps

The title compound was synthesized from (R)-4-(9-cyclopentyl-7-fluoro-5-methyl-6-oxo-7-vinyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxybenzoic acid as described in the general procedure for amide bond synthesis using HATU and 4-amino 1-methylpiperidine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.19-1.90 (m, 8 H) 2.05 (dd, J=4.29, 1.52 Hz, 4 H) 2.16-2.28 (m, 2 H) 2.34 (s, 3 H) 2.83 (br. s., 2 H) 3.39 (s, 3 H) 3.69-3.89 (m, 2 H) 3.96 (s, 3 H) 4.00-4.10 (m, 1 H) 4.97 (quin, J=8.46 Hz, 1 H) 5.37 (d, J=11.12 Hz, 1 H) 5.50 (dd, J=17.30, 1.89 Hz, 1 H) 6.02 (ddd, J=17.30, 14.53, 10.86 Hz, 1 H) 6.67 (d, J=7.07 Hz, 1 H) 7.56 (d, J=7.07 Hz, 1 H) 7.76 (s, 1 H) 7.96 (s, 1 H) 8.37 (d, J=15.16 Hz, 1 H), [M+H] calc'd for C29H37F2N7O3 570; found 570.

Provenance & Evidence