Acetic Acid → 4-Amino-2-fluoro-3-methoxybenzoic acid

Participants

Reaction Steps

A solution of 2-fluoro-3-methoxy-4-nitrobenzonitrile (170 mg) in H2SO4 and H2O (0.5 mL/0.5 mL) was heated at 100° C. for 18 h. After which, it was separated between ethyl acetate and water. Organic extract was dried and concentrated to give a residue, which was then dissolved in a mixture of methanol and acetic acid (2 mL/2 mL) and was hydrogenated using hydrogen balloon overnight. The solution was filtered through celite, and the filtrate concentrated to give a read solid as the product. [M+H] calc'd for C8H8FNO3, 186; found 186.

Provenance & Evidence