Acetone → HCID 57955608, compound

Participants

Reaction Steps

The title compound was synthesized by following the Reductive Amination Procedure using N-(azetidin-3-yl)-4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxybenzamide and acetone. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.85 (d, J=6.06 Hz, 6 H) 1.44-1.80 (m, 6 H) 1.95 (br. s., 2 H) 2.27 (m, 6.09 Hz, 1 H) 2.89 (t, J=7.33 Hz, 2 H) 3.50 (t, J=7.33 Hz, 2 H) 3.92 (s, 3 H) 4.08 (t, J=13.89 Hz, 2 H) 4.29-4.42 (m, 1 H) 4.72-4.89 (m, 1 H) 7.19 (d, J=6.82 Hz, 1 H) 8.05 (s, 1 H) 8.25 (d, J=13.39 Hz, 1 H) 8.29-8.32 (m, 1 H) 8.40 (d, J=7.07 Hz, 1 H). [M+H] calculated for C27H34F3N7O3, 562; found 562.

Provenance & Evidence