Cyclopentanone → HCID 57955592, compound

Participants

Reaction Steps

The title compound was synthesized by following the Reductive Amination Procedure using N-(azetidin-3-yl)-4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxybenzamide and cyclopentanone. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.23-1.35 (m, 2 H) 1.38-1.78 (m, 11 H) 1.96 (br. s., 2 H) 2.67 (br. s., 1 H) 2.87 (t, J=7.33 Hz, 2 H) 3.49 (t, J=7.33 Hz, 2 H) 3.91 (s, 3 H) 4.08 (t, J=13.77 Hz, 2 H) 4.33-4.44 (m, 1 H) 4.78-4.88 (m, 1 H) 7.19 (d, J=6.57 Hz, 1 H) 8.05 (s, 1 H) 8.25 (d, J=13.39 Hz, 1 H) 8.30 (s, 1 H) 8.41 (dd, J=6.82, 3.03 Hz, 1 H). [M+H] calculated for C29H36F3N7O3, 588; found 588.

Provenance & Evidence