4-Amino-1-methylpiperidine → HCID 57955606, compound

Participants

Reaction Steps

The title compound was synthesized from 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-methylbenzoic acid as described in the general procedure for amide bond synthesis using HATU and 1-methylpiperidin-4-amine. The final compound was purified by reverse phase HPLC and basified to give the free base. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.36-1.77 (m, 11 H) 1.98 (m, 4 H) 2.16 (s, 3 H) 2.31 (s, 3 H) 2.75 (d, J=11 Hz, 2 H) 3.17 (br. s., 2 H) 3.67 (d, J=7 Hz, 1 H) 4.03 (t, J=14 Hz, 3 H) 4.81 (m, 1 H) 7.22 (d, J=8 Hz, 1 H) 7.46 (d, J=8 Hz, 1 H) 7.68 (br. s., 1 H) 7.99 (d, J=8 Hz, 1 H) 8.25 (s, 1 H) 9.51 (br. s., 1 H). [M+H] calc'd for C27H35F2N7O2, 528; found 528.

Provenance & Evidence