HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Amino-1-methylpiperidine → HCID 57955559, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Amino-1-methylpiperidine | HCID 2737531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 67117752 | HCID 67117752 | — |
| Product | HCID 57955559 | HCID 57955559 | — |
Reaction Steps
The title compound was synthesized from 5-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)picolinic acid as described in the general procedure for amide bond synthesis using HATU and 1-methylpiperidin-4-amine. The final compound was purified by reverse phase HPLC. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.44-2.04 (m, 13 H) 2.77 (d, J=5 Hz, 2 H) 3.01-3.22 (m, 2 H) 3.34 (s, 3 H) 3.47 (d, J=11 Hz, 2 H) 4.08 (m, 3 H) 4.80 (m, 1 H) 7.85-8.02 (m, 1 H) 8.30 (s, 1 H) 8.44 (dd, J=9, 2 Hz, 1 H) 8.69 (d, J=8 Hz, 1 H) 8.80-8.92 (m, 1 H) 9.85-10.01 (m, 1 H). [M+H] calc'd for C25H32F2N8O2, 516; found 516.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318727B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-25a8886dc9d54e0fa74947d87677b16a |
| Source note | uspto-grants-2012_11 |