4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)aniline → HCID 57955643, compound

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Reaction Steps

The title compound was prepared in a manner analogous to compound 149 from 4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[5,4-b][1,4]diazepin-2-ylamino)-3-methoxybenzoic acid and 4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)aniline with yield 46 mg (34%). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.43-1.72 (m, 6 H) 1.99 (br. s., 2 H) 2.23 (s, 3 H) 2.47 (br.s., 4 H) 2.85 (t, J=4.29 Hz, 4 H) 3.99 (s, 3 H) 4.07 (t, J=12 Hz, 2 H) 4.80 (t, J=7.96 Hz, 1 H) 7.46-7.73 (m, 3 H) 7.97-8.10 (m, 2 H) 8.14 (d, J=2.53 Hz, 1 H) 8.29 (s, 1 H) 8.38 (d, J=8.34 Hz, 1 H) 10.31 (s, 1 H). [M+H] calc'd for C33H37F5N8O3, 689; found 689.

Provenance & Evidence