Methanesulfonyl chloride → HCID 67117743, compound

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Reaction Steps

To a solution of N-(azetidin-3-yl)-4-(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-2-fluoro-5-methoxybenzamide (100 mg, 0.19 mmol) in DCM (2.5 mL, 1:2:2) was added DIEA (50 μL, 0.285 mmol), followed by methanesulfonyl chloride (23 μL, 0.21 mmol). After stirring overnight the solvent was removed and the product purified by reverse phase HPLC, free based, and lyophilized to yield a white solid (9.3 mg, 9%). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.54-1.79 (m, 6 H) 1.96 (br. s., 2 H) 3.05 (s, 3 H) 3.92 (s, 3 H) 3.94 (d, J=1.77 Hz, 2 H) 4.03-4.15 (m, 4 H) 4.61-4.72 (m, 1 H) 4.76-4.87 (m, 1 H) 7.24 (d, J=6.57 Hz, 1 H) 8.08 (s, 1 H) 8.27 (d, 1 H) 8.31 (s, 1 H) 8.73 (d, J=3.79 Hz, 1 H). [M+H] calc'd for C25H30F3N7O5S, 598; found 598.

Provenance & Evidence