Sodium Hydroxide → HCID 67299617, compound

Participants

Reaction Steps

4-{4-[2-(2-phenylpyridinylamino)ethoxy]phenyl}butanoic acid methyl ester (149 mg) from the previous step was dissolved in methanol (2 mL) and tetrahydrofuran (2 mL), and 2N sodium hydroxide aqueous solution (0.6 mL) was added, then stirred overnight at room temperature. The reaction solution was concentrated with 2N hydrochloric acid (0.6 mL), then the residue was purified by silica gel flash column chromatography (developing solvent: chloroform:methanol=19:1) to give the above-identified compound (115 mg, yield 80%) as a colorless crystal.

Provenance & Evidence