HRID1881050

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID69705

4-Methoxybenzeneethanol

C9H12O2

HCID57481429

未命名化合物

结构：CC(C)(Sc1cnc(NC(=O)N(CCCCc2ccccc2)[C@H]2CC[C@H](C)CC2)s1)C(=O)O

HCID178460760

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CCN(C(=O)Nc2ncc(SCC(C)(C)C(=O)O)s2)[C@H]2CC[C@H](C)CC2)cc1

HCID178490371

未命名化合物

PROCEDURE

实验过程

The compound was prepared following an analogous procedure to the one described for the synthesis of 2-methyl-2-{2-[3-(trans-4-methyl-cyclohexyl)-3-(4-phenyl-butyl) -ureido]-thiazol-5-ylsulfanyl}-propionic acid using 2-(4-methoxy-phenyl)-ethanol and 3-(2-amino-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid ethyl ester.

WORKUP

后处理

customThe compound was prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-46951233026f4cc5bb1dabd294e97577
来源数据集: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08318778B2
来源说明: uspto-grants-2012_11

反应 SMILES

CC([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:27]2[CH2:32][CH2:31][C@H:30]([CH3:33])[CH2:29][CH2:28]2)[CH2:17][CH2:18]CCC2C=CC=CC=2)=[O:15])=[N:10][CH:9]=1)(C)C(O)=O.[CH3:34][O:35][C:36]1[CH:41]=[CH:40][C:39](CCO)=[CH:38][CH:37]=1.C([O:47][C:48](=[O:60])[C:49]([CH3:59])([CH3:58])[CH2:50]SC1SC(N)=NC=1)C>>[CH3:34][O:35][C:36]1[CH:37]=[CH:38][C:39]([CH2:18][CH2:17][N:16]([C@H:27]2[CH2:28][CH2:29][C@H:30]([CH3:33])[CH2:31][CH2:32]2)[C:14](=[O:15])[NH:13][C:11]2[S:12][C:8]([S:7][CH2:50][C:49]([CH3:59])([CH3:58])[C:48]([OH:60])=[O:47])=[CH:9][N:10]=2)=[CH:40][CH:41]=1