Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoate → HCID 178460775, compound

HRID 1881052Notes

Reaction equation

HRID 1881052 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([N:8]([CH2:22][CH2:23][S:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:9](=[O:21])NC2SC(SCC(O)=O)=CN=2)[CH2:4][CH2:3]1.C([O:33][C:34](=[O:45])[C:35]([S:38][C:39]1[S:43][C:42]([NH2:44])=[N:41][CH:40]=1)([CH3:37])[CH3:36])C>>[CH3:37][C:35]([S:38][C:39]1[S:43][C:42]([NH:44][C:9]([N:8]([C@H:5]2[CH2:4][CH2:3][C@H:2]([CH3:1])[CH2:7][CH2:6]2)[CH2:22][CH2:23][S:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)=[O:21])=[N:41][CH:40]=1)([CH3:36])[C:34]([OH:33])=[O:45]

Participants

3

Reactant 2

HCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178461344HCID 178461344, compound

Product 1

HCID 178460775HCID 178460775, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[3-(trans-4-methyl-cyclohexyl)-3-(2-phenylsulfanyl-ethyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-b6511947cf024335bd822fb5611e15bd
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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