Benzenebutanol → HCID 178461324, compound

HRID 1881058Notes

Reaction equation

HRID 1881058 reaction equation
C[C:2]([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:27]2[CH2:32][CH2:31][C@H:30]([CH3:33])[CH2:29][CH2:28]2)[CH2:17][CH2:18][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[O:15])=[N:10][CH:9]=1)(C)[C:3]([OH:5])=[O:4].C1(CCCCO)C=CC=CC=1.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH3:33][C@H:30]1[CH2:31][CH2:32][C@H:27]([N:16]([CH2:17][CH2:18][CH2:19][CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:14](=[O:15])[NH:13][C:11]2[S:12][C:8]([S:7][CH2:2][C:3]([OH:5])=[O:4])=[CH:9][N:10]=2)[CH2:28][CH2:29]1

Participants

4

Reactant 3

HCID 76889BenzenebutanolHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178460760HCID 178460760, compound

Product 1

HCID 178461324HCID 178461324, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 2-methyl-2-{2-[3-(trans-4-methyl-cyclohexyl)-3-(4-phenyl-butyl) -ureido]-thiazol-5-ylsulfanyl}-propionic acid using 4-phenyl butan-1-ol and (2-aminothiazol-5-ylsulfanyl) acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-e9133164e740410c9acd224a98fe3cf9
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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