{2-[3-(2-Benzyloxy-ethyl)-3-(4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid → HCID 178461339, compound

HRID 1881064Notes

Reaction equation

HRID 1881064 reaction equation
COC1C=CC([CH2:9][CH2:10][N:11]([C@H:26]2[CH2:31][CH2:30][C@H:29]([CH3:32])[CH2:28][CH2:27]2)[C:12](=[O:25])[NH:13][C:14]2[S:15][C:16]([S:19]([CH2:21][C:22]([OH:24])=[O:23])=[O:20])=[CH:17][N:18]=2)=CC=1.[CH2:33]([O:40]CCN(C1CCC(C)CC1)C(=O)NC1SC(SCC(O)=O)=CN=1)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1>>[CH2:33]([O:40][CH2:9][CH2:10][N:11]([C@H:26]1[CH2:31][CH2:30][C@H:29]([CH3:32])[CH2:28][CH2:27]1)[C:12](=[O:25])[NH:13][C:14]1[S:15][C:16]([S:19]([CH2:21][C:22]([OH:24])=[O:23])=[O:20])=[CH:17][N:18]=1)[C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1

Participants

3

Reactant 2

HCID 57668214{2-[3-(2-Benzyloxy-ethyl)-3-(4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acidHCID 178490375HCID 178490375, compound

Product 1

HCID 178461339HCID 178461339, compound

Procedure

The compound was prepared as previously described for {2-[3-[2-(4-methoxy -phenyl)-ethyl]-3-(trans-4-methyl-cyclohexyl)-ureido]-thiazole-5-sulfinyl}-acetic acid using {2-[3-(2-benzyloxy-ethyl)-3-(4-methyl-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-43a3f7e6a318465c983418ceda41d0b3
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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