1-(Bromomethyl)-2-chloro-4-fluorobenzene → HCID 178460773, compound

HRID 1881066Notes

Reaction equation

HRID 1881066 reaction equation
[Cl:1][C:2]1[CH:35]=[CH:34][CH:33]=[CH:32][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])[NH:10][C:11]1[S:12][C:13]([S:16]CC(C)(C)C(O)=O)=[CH:14][N:15]=1.BrCC1C=CC([F:44])=CC=1Cl.C([O:48][C:49](=[O:60])[C:50](SC1SC(N)=NC=1)([CH3:52])[CH3:51])C>>[Cl:1][C:2]1[CH:35]=[C:34]([F:44])[CH:33]=[CH:32][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:26][CH2:27][C@H:28]([CH3:31])[CH2:29][CH2:30]1)[C:9](=[O:24])[NH:10][C:11]1[S:12][C:13]([S:16][C:50]([CH3:52])([CH3:51])[C:49]([OH:48])=[O:60])=[CH:14][N:15]=1

Participants

4

Reactant 3

HCID 27250621-(Bromomethyl)-2-chloro-4-fluorobenzeneHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178454946HCID 178454946, compound

Product 1

HCID 178460773HCID 178460773, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 3-{2-[3-[2-(2-chloro-benzyloxy)-ethyl]-3-(trans-4-methyl -cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid using 1-bromomethyl-2-chloro-4-fluoro-benzene and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-b2a37605831540d6bc34d87e3fd29666
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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