1-(Bromomethyl)-2,4-difluorobenzene → HCID 178460774, compound

HRID 1881068Notes

Reaction equation

HRID 1881068 reaction equation
ClC1C=CC=CC=1C[O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])NC1SC(SCC(C)(C)C(O)=O)=CN=1.Br[CH2:37][C:38]1[CH:43]=[CH:42][C:41]([F:44])=[CH:40][C:39]=1[F:45].C([O:48][C:49](=[O:60])[C:50]([S:53][C:54]1[S:58][C:57]([NH2:59])=[N:56][CH:55]=1)([CH3:52])[CH3:51])C>>[F:45][C:39]1[CH:40]=[C:41]([F:44])[CH:42]=[CH:43][C:38]=1[CH2:37][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:26][CH2:27][C@H:28]([CH3:31])[CH2:29][CH2:30]1)[C:9](=[O:24])[NH:59][C:57]1[S:58][C:54]([S:53][C:50]([CH3:51])([CH3:52])[C:49]([OH:48])=[O:60])=[CH:55][N:56]=1

Participants

4

Reactant 3

HCID 902971-(Bromomethyl)-2,4-difluorobenzeneHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178454946HCID 178454946, compound

Product 1

HCID 178460774HCID 178460774, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 3-{2-[3-[2-(2-chloro-benzyloxy)-ethyl]-3-(trans-4-methyl -cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid using 1-bromomethyl -2,4-difluoro-benzene and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-ee66bc8e00a64404b8a76ed1e11f9854
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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