3-(2-Amino-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid ethyl ester → HCID 178454941, compound

HRID 1881071Notes

Reaction equation

HRID 1881071 reaction equation
CC([S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[CH2:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:15])=[N:10][CH:9]=1)(C)C(O)=O.C([O:34][C:35](=[O:47])[C:36]([CH3:46])([CH3:45])[CH2:37]SC1SC(N)=NC=1)C>>[CH3:37][C:36]([CH3:46])([CH2:45][S:7][C:8]1[S:12][C:11]([NH:13][C:14]([N:16]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[CH2:17][CH2:18][C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)=[O:15])=[N:10][CH:9]=1)[C:35]([OH:47])=[O:34]

Participants

3

Reactant 2

HCID 574814293-(2-Amino-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid ethyl esterHCID 178460750HCID 178460750, compound

Product 1

HCID 178454941HCID 178454941, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 2-methyl-2-{2-[3-(trans-4-methyl-cyclohexyl)-3-phenethyl -ureido]-thiazol-5-ylsulfanyl}-propionic acid using 3-(2-amino-thiazol-5-ylsulfanyl)-2,2-dimethyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-56967025a77e4b3cb344581cb0bbac0d
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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