4-(Trifluoromethoxy)thiophenol → HCID 178460769, compound

HRID 1881088Notes

Reaction equation

HRID 1881088 reaction equation
CO[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9][CH2:10][CH2:11][CH2:12][N:13]([C@H:29]1[CH2:34][CH2:33][C@H:32]([CH3:35])[CH2:31][CH2:30]1)[C:14](=[O:28])[NH:15][C:16]1[S:17][C:18]([S:21][C:22]([CH3:27])([CH3:26])[C:23]([OH:25])=[O:24])=[CH:19][N:20]=1.[F:36][C:37]([F:47])([F:46])[O:38]C1C=CC(S)=CC=1>>[CH3:26][C:22]([S:21][C:18]1[S:17][C:16]([NH:15][C:14]([N:13]([C@H:29]2[CH2:30][CH2:31][C@H:32]([CH3:35])[CH2:33][CH2:34]2)[CH2:12][CH2:11][CH2:10][S:9][C:4]2[CH:3]=[CH:8][C:7]([O:38][C:37]([F:47])([F:46])[F:36])=[CH:6][CH:5]=2)=[O:28])=[N:20][CH:19]=1)([CH3:27])[C:23]([OH:25])=[O:24]

Participants

3

Reactant 2

HCID 27773604-(Trifluoromethoxy)thiophenolHCID 178489631HCID 178489631, compound

Product 1

HCID 178460769HCID 178460769, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis 2-{2-[3-[3-(2-methoxy-phenylsulfanyl)-propyl]-3-(trans-4-methyl -cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2-methyl-propionic acid using 4-trifluoromethoxy -thiophenol.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-d46a4bd895a94e74850a5c27f813e05a
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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