3-(3-Fluoro-4-methoxybenzoyl)propionic acid → HCID 178491461, compound

HRID 1881109Notes

Reaction equation

HRID 1881109 reaction equation
ClC1C=C([CH2:8][CH2:9][CH2:10][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)C=CC=1.[F:32][C:33]1[CH:34]=[C:35]([C:41](=[O:47])CCC(O)=O)[CH:36]=[CH:37][C:38]=1[O:39][CH3:40].C(OC(=O)CSC1SC(N)=NC=1)C>>[F:32][C:33]1[CH:34]=[C:35]([CH:41]([OH:47])[CH2:8][CH2:9][CH2:10][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)[CH:36]=[CH:37][C:38]=1[O:39][CH3:40]

Participants

4

Reactant 3

HCID 676713-(3-Fluoro-4-methoxybenzoyl)propionic acidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178461316HCID 178461316, compound

Product 1

HCID 178491461HCID 178491461, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl -cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 4-(3-fluoro-4-methoxy-phenyl)-4-oxo-butyric acid and (2-aminothiazol-5-ylsulfanyl) acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-6b06f1a9bb7b4f8a8078e0004d4f0348
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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