HCID 86639123, compound → HCID 178461319, compound

HRID 1881112Notes

Reaction equation

HRID 1881112 reaction equation
ClC1C=C([CH2:8][CH2:9][CH2:10][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)C=CC=1.C(OC(=O)CSC1SC(N)=NC=1)C.[NH:45]1[C:53]2[C:48](=[CH:49][CH:50]=[CH:51][CH:52]=2)[C:47](CCC(O)=O)=[CH:46]1>>[NH:45]1[C:53]2[C:48](=[CH:49][CH:50]=[CH:51][CH:52]=2)[C:47]([CH2:8][CH2:9][CH2:10][N:11]([C@H:25]2[CH2:26][CH2:27][C@H:28]([CH3:31])[CH2:29][CH2:30]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)=[CH:46]1

Participants

3

Reactant 2

HCID 86639123HCID 86639123, compoundHCID 178461316HCID 178461316, compound

Product 1

HCID 178461319HCID 178461319, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl -cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 3-(1H-indol-3-yl)-propionic acid (2-aminothiazol-5-ylsulfanyl) acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-518c107d0b384838af57bbfaadbb3e8b
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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