4-(3,4-Dimethoxyphenyl)butanoic acid → HCID 178490105, compound

HRID 1881113Notes

Reaction equation

HRID 1881113 reaction equation
ClC1C=C(CC[CH2:10][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)C=CC=1.[CH3:32][O:33][C:34]1[CH:35]=[C:36]([CH2:42][CH2:43][CH2:44]C(O)=O)[CH:37]=[CH:38][C:39]=1[O:40][CH3:41].C(OC(=O)CSC1SC(N)=NC=1)C>>[CH3:32][O:33][C:34]1[CH:35]=[C:36]([CH2:42][CH2:43][CH2:44][CH2:10][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)[CH:37]=[CH:38][C:39]=1[O:40][CH3:41]

Participants

4

Reactant 3

HCID 3236754-(3,4-Dimethoxyphenyl)butanoic acidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178461316HCID 178461316, compound

Product 1

HCID 178490105HCID 178490105, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl -cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 4-(3,4-dimethoxy-phenyl)-butyric acid and (2-aminothiazol-5-ylsulfanyl) acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-e9f4aa78885d4c70830b0e655e91404c
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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