4-(Bromomethyl)pyridine hbr → HCID 178461342, compound

HRID 1881141Notes

Reaction equation

HRID 1881141 reaction equation
Cl[C:2]1[CH:35]=C[CH:33]=[CH:32][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])[NH:10][C:11]1[S:12][C:13]([S:16]CC(C)(C)C(O)=O)=[CH:14][N:15]=1.Br.BrCC1C=C[N:42]=CC=1.C([O:47][C:48](=[O:57])[CH2:49]SC1SC(N)=NC=1)C>>[CH3:31][C@H:28]1[CH2:29][CH2:30][C@H:25]([N:8]([CH2:7][CH2:6][O:5][CH2:4][C:3]2[CH:2]=[CH:35][N:42]=[CH:33][CH:32]=2)[C:9](=[O:24])[NH:10][C:11]2[S:12][C:13]([S:16][CH2:49][C:48]([OH:57])=[O:47])=[CH:14][N:15]=2)[CH2:26][CH2:27]1

Participants

4

Reactant 3

HCID 127522194-(Bromomethyl)pyridine hbrHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178454946HCID 178454946, compound

Product 1

HCID 178461342HCID 178461342, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 3-{2-[3-[2-(2-chloro-benzyloxy)-ethyl]-3-(trans-4-methyl -cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid using 4-bromomethylpyridine hydrobromide and (2-aminothiazol-5-ylsulfanyl) acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-055a247431344d3f9dc55bd5f6b51000
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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