Benzenepentanoic acid → HCID 178461328, compound

HRID 1881144Notes

Reaction equation

HRID 1881144 reaction equation
ClC1C=C([CH2:8][CH2:9][CH2:10][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)C=CC=1.[C:32]1([CH2:38][CH2:39]CCC(O)=O)[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.C(OC(=O)CSC1SC(N)=NC=1)C>>[CH3:31][C@H:28]1[CH2:27][CH2:26][C@H:25]([N:11]([CH2:10][CH2:9][CH2:8][CH2:39][CH2:38][C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:12](=[O:24])[NH:13][C:14]2[S:15][C:16]([S:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][N:18]=2)[CH2:30][CH2:29]1

Participants

4

Reactant 3

HCID 16757Benzenepentanoic acidHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178461316HCID 178461316, compound

Product 1

HCID 178461328HCID 178461328, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl -cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 5-phenyl-pentanoic acid and (2-aminothiazol-5-ylsulfanyl) acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-f1f63c38a5d44420857330ea400e9bfa
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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