Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoate → HCID 178460758, compound

HRID 1881146Notes

Reaction equation

HRID 1881146 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])NC2SC(SCC(O)=O)=CN=2)[CH:5]=[CH:6][CH:7]=1.C([O:34][C:35](=[O:46])[C:36]([S:39][C:40]1[S:44][C:43]([NH2:45])=[N:42][CH:41]=1)([CH3:38])[CH3:37])C>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][CH2:10][N:11]([C@H:25]2[CH2:26][CH2:27][C@H:28]([CH3:31])[CH2:29][CH2:30]2)[C:12](=[O:24])[NH:45][C:43]2[S:44][C:40]([S:39][C:36]([CH3:37])([CH3:38])[C:35]([OH:34])=[O:46])=[CH:41][N:42]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178461316HCID 178461316, compound

Product 1

HCID 178460758HCID 178460758, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl -cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-7565c2d7478b4711b50e3679139b8d83
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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