3-(4-Fluorophenyl)propionic acid → HCID 178460759, compound

HRID 1881147Notes

Reaction equation

HRID 1881147 reaction equation
ClC1C=C(CCC[N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])NC2SC(SCC(O)=O)=CN=2)C=CC=1.[F:32][C:33]1[CH:38]=[CH:37][C:36]([CH2:39][CH2:40][C:41](O)=O)=[CH:35][CH:34]=1.C([O:46][C:47](=[O:58])[C:48]([S:51][C:52]1[S:56][C:55]([NH2:57])=[N:54][CH:53]=1)([CH3:50])[CH3:49])C>>[F:32][C:33]1[CH:34]=[CH:35][C:36]([CH2:39][CH2:40][CH2:41][N:11]([C@H:25]2[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]2)[C:12](=[O:24])[NH:57][C:55]2[S:56][C:52]([S:51][C:48]([CH3:49])([CH3:50])[C:47]([OH:46])=[O:58])=[CH:53][N:54]=2)=[CH:37][CH:38]=1

Participants

4

Reactant 3

HCID 1363023-(4-Fluorophenyl)propionic acidHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178461316HCID 178461316, compound

Product 1

HCID 178460759HCID 178460759, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of {2-[-3-[3-(3-chloro-phenyl)-propyl]-3-(trans-4-methyl -cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid using 3-(4-fluoro-phenyl)-propanoic-acid and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-4a7dc7685e0b4ec3b1fb57ad7912d547
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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