HCID 67094346, compound → HCID 67094263, compound

HRID 1881154Notes

Reaction equation

HRID 1881154 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:16][C:15]3[C:10](=[CH:11][C:12]([OH:18])=[C:13]([OH:17])[CH:14]=3)[C:9]2=[O:19])=[CH:4][CH:3]=1>S(=O)(=O)(O)O.C(OC(=O)C)(=O)C>[C:13]([O:17][C:13]1[CH:14]=[C:15]2[C:10]([C:9](=[O:19])[N:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[CH2:16]2)=[CH:11][C:12]=1[O:18][C:9](=[O:19])[CH3:10])(=[O:17])[CH3:12]

Participants

4

Reactant 1

HCID 67094346HCID 67094346, compound

Product 1

HCID 67094263HCID 67094263, compound

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 7918Acetic AnhydrideSolvent

Procedure

2-(4-Chloro-phenyl)-5,6-dihydroxy-2,3-dihydro-isoindol-1-one (0.79 g of raw material) and acetic anhydride (10 ml) was stirred in 80° C. with one drop of sulfuric acid as a catalyst for one hour. The mixture was poured into ice water, filtered and recrystallized from acetic acid.

Workup

  1. filtrationfiltered
  2. customrecrystallized from acetic acid

Sources & evidence

ORD record
ord-363aed6afee04506a47aeee2e9617437
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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