Ethanol → HCID 15982972, compound

HRID 1881162Notes

Reaction equation

HRID 1881162 reaction equation
[Cl:1][C:2]1[C:3]2[CH:13]=[C:12]([OH:14])[C:11]([OH:15])=[C:10]([N+:16]([O-:18])=[O:17])[C:4]=2[S:5][C:6]=1[C:7]([OH:9])=[O:8].S(Cl)(Cl)=O.[CH2:23](O)[CH3:24]>>[CH2:23]([O:8][C:7]([C:6]1[S:5][C:4]2[C:10]([N+:16]([O-:18])=[O:17])=[C:11]([OH:15])[C:12]([OH:14])=[CH:13][C:3]=2[C:2]=1[Cl:1])=[O:9])[CH3:24]

Participants

4

Reactant 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 159829713-Chloro-5,6-dihydroxy-7-nitro-1-benzothiophene-2-carboxylic acid

Product 1

HCID 15982972HCID 15982972, compound

Procedure

3-Chloro-5,6-dihydroxy-7-nitro-benzo[b]thiophene-2-carboxylic acid (70 mg) from Example 4, ethanol (2 ml) and thionyl chloride (0.16 ml) were refluxed for 4 hours. Ethanol was evaporated. The residue was heated with absolute ethanol and the hot mixture was filtered. The product was dried under vacuum.

Workup

  1. customEthanol was evaporated
  2. temperatureThe residue was heated with absolute ethanol
  3. filtrationthe hot mixture was filtered
  4. customThe product was dried under vacuum

Sources & evidence

ORD record
ord-e1bb70465d384df5ba6c9d871cf0bef4
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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