Hydrochloric Acid → HCID 67094484, compound

Participants

Reaction Steps

3-Chloro-5-benzyloxy-6-methoxy-benzo[b]thiophene-2-carboxylic acid methyl ester (0.7 g), acetic acid (17.5 ml) and concentrated hydrochloride acid (2.1 ml) was refluxed for six hours. The mixture was cooled and evaporated to dryness. The resultant mixture was extracted first into diethyl ether and then into a solution of 1M sodium hydroxide. The water phase was acidified with 6M hydrochloric acid. The solution was stirred in cool for two hours and filtered. The solid was washed with water and dried under vacuum. The product was a mixture of two compounds and it was used for the next step without any purification.

Provenance & Evidence