Boron tribromide → HCID 67094183, compound

HRID 1881170Notes

Reaction equation

[Cl:1][C:2]1[C:3]2[CH:18]=[C:17]([O:19]C)[C:16]([O:21]C)=[CH:15][C:4]=2[S:5][C:6]=1[C:7]([N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)=[O:8].B(Br)(Br)Br>ClCCl>[Cl:1][C:2]1[C:3]2[CH:18]=[C:17]([OH:19])[C:16]([OH:21])=[CH:15][C:4]=2[S:5][C:6]=1[C:7]([N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1)=[O:8]

Participants

Conditions

Temperature: -20 °C

Procedure

(3-Chloro-5,6-dimethoxy-benzo[b]thiophen-2-yl)-morpholin-4-yl-methanone (8.6 g) was suspended in dichloromethane (50 ml) under nitrogen, cooled to −20° C. and treated dropwise with 1M boron tribromide (100 ml) in dichloromethane. The resultant suspension was stirred at −20° C. for 30 min and then in cool overnight. The mixture was poured into ice-cold water and stirred for 30 min at room temperature. The product was filtered and washed with water.

Workup

additionThe mixture was poured into ice-cold water
filtrationThe product was filtered
washwashed with water

Sources & evidence

ORD record: ord-2829695a070f496bbceb7cf612e63aac
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08318785B2

Reaction notes

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