Hydrogen Bromide → 5,6-Dihydroxy-7-nitro-1-benzothiophene-2-carboxylic acid

Participants

Reaction Steps

5,6-Diethoxy-7-nitro-benzo[b]thiophene-2-carboxylic acid methyl ester (160 mg), hydrobromic acid (8 ml) and acetic acid (8 ml) was refluxed for 6 hours and stirred at room temperature overnight. The solid was filtered and washed with a solution of acetic acid and hydrobromic acid (1:1) and water. The product was recrystallized from acetonitrile.

Provenance & Evidence