HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 86633442, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | HCID 15947956 | HCID 15947956 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86633442 | HCID 86633442 | — |
Reaction Steps
4-Benzyloxy-2-hydroxy-5-methoxybenzaldehyde (2.9 g), ethyl bromoacetate (2.3 g) and 1,8-diazabicyclo[5.4.0]undec-7-ene (2.1 g) in N,N-dimethylformamide (30 ml) were heated at 100° C. under nitrogen for 5 hours. After cooling to room temperature, water was added and the mixture extracted with ethyl acetate. Ethyl acetate was washed with 1 N NaOH and 1 N HCl, dried with Na2SO4 and evaporated to dryness.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318785B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-0f7fa2acdaeb45d983b489bb2c2528f6 |
| Source note | uspto-grants-2012_11 |