Methanol → HCID 67094302, compound

HRID 1881198Notes

Reaction equation

HRID 1881198 reaction equation
C[O:2][C:3]1[C:4]([O:14]C)=[CH:5][C:6]2[S:10][N:9]([CH3:11])[C:8](=[O:12])[C:7]=2[CH:13]=1.CO>ClCCl>[OH:2][C:3]1[C:4]([OH:14])=[CH:5][C:6]2[S:10][N:9]([CH3:11])[C:8](=[O:12])[C:7]=2[CH:13]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 67094182HCID 67094182, compound

Product 1

HCID 67094302HCID 67094302, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
-10 °C

Procedure

To a suspension of 5,6-dimethoxy-2-methylbenzo[d]isothiazol-3-one (0.35 g) in dichloromethane (30 ml) boron tribromide (3.1 ml, 1 M solution in dichloromethane) was added at −40° C. The mixture was allowed to warm to −10° C. Next day methanol (30 ml) was added and the mixture was evaporated to dryness. To the residue sodium sulfite solution (9 ml, 5% in water) and brine (9 ml) were added. After stirring at 0° C. the precipitate was filtered.

Workup

  1. additionwas added at −40° C
  2. customthe mixture was evaporated to dryness
  3. additionTo the residue sodium sulfite solution (9 ml, 5% in water) and brine (9 ml) were added
  4. filtrationwas filtered

Sources & evidence

ORD record
ord-6c61dc63f8f4450ab83a2ab8e88222ac
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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