HCID 67094363, compound → HCID 15983106, compound

HRID 1881202Notes

Reaction equation

HRID 1881202 reaction equation
[OH:1][C:2]1[C:12]([O:13]C(=O)C)=[CH:11][C:5]2[C:6](=[O:10])[N:7]([CH3:9])[S:8][C:4]=2[C:3]=1[N+:17]([O-:19])=[O:18]>Cl.CO>[OH:13][C:12]1[C:2]([OH:1])=[C:3]([N+:17]([O-:19])=[O:18])[C:4]2[S:8][N:7]([CH3:9])[C:6](=[O:10])[C:5]=2[CH:11]=1

Participants

3

Reactant 1

HCID 67094363HCID 67094363, compound

Product 1

HCID 15983106HCID 15983106, compound

Reagents, catalysts & solvents 1

HCID 21893726Hydrochloride methanolSolvent

Procedure

Acetic acid 6-hydroxy-2-methyl-7-nitro-3-oxo-2,3-dihydro-benzo[d]isothiazol-5-yl ester (0.046 g) in methanol-HCl (14:1, 7 ml) was heated at 60° C. for 3 hours. The mixture was evaporated to dryness. The crude product was purified by flash chromatography using ethyl acetate as an eluent and followed by crystallization from isopropanol-methanol.

Workup

  1. customThe mixture was evaporated to dryness
  2. customThe crude product was purified by flash chromatography
  3. customfollowed by crystallization from isopropanol-methanol

Sources & evidence

ORD record
ord-d924f880c6e54d0290ac10287528c25a
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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