Methanol → HCID 67094361, compound

HRID 1881204Notes

Reaction equation

HRID 1881204 reaction equation
C[O:2][C:3]1[C:20]([O:21]C)=[CH:19][C:6]2[S:7][C:8]([C:11]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[O:12])=[C:9]([CH3:10])[C:5]=2[CH:4]=1.CO>ClCCl>[OH:2][C:3]1[C:20]([OH:21])=[CH:19][C:6]2[S:7][C:8]([C:11]([N:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)=[O:12])=[C:9]([CH3:10])[C:5]=2[CH:4]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 67094298HCID 67094298, compound

Product 1

HCID 67094361HCID 67094361, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (5,6-dimethoxy-3-methylbenzo[b]thiophen-2-yl)morpholin-4-yl-methanone (0.80 g) in dichloromethane (8 ml) boron tribromide (5.2 ml, 2 M solution in dichloromethane) was added at 0° C. The mixture was allowed to warm to room temperature. After 2 hours at room temperature methanol (16 ml) was added and solvents were evaporated. To the residue sodium sulfite solution (16 ml, 5% in water) was added and after stirring for 0.5 hour the precipitate was filtered.

Workup

  1. customsolvents were evaporated
  2. additionTo the residue sodium sulfite solution (16 ml, 5% in water) was added
  3. filtrationwas filtered

Sources & evidence

ORD record
ord-c77f80eb4f9b4fc7ad4d0c5e891f6006
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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