Morpholine → HCID 67094289, compound

Participants

Reaction Steps

Acetic acid 6-acetoxy-3-oxo-1,3-dihydro-isobenzofuran-5-yl ester (5.0 g) was dissolved in N,N-dimethylformamide (100 ml) followed by addition of morpholine (1.78 ml). The solution was stirred at room temperature overnight followed by concentration in reduced pressure. Ethyl acetate (200 ml) was added to the remainder. The organic phase was washed two times with a mixture of aqueous HCl (50 ml, 2M) and brine (50 ml). The organic solvent was dried over anhydrous Na2SO4, filtered and evaporated to dryness.

Provenance & Evidence