Nitric Acid → HCID 67094449, compound

Participants

Reaction Steps

Acetic acid 6-hydroxy-3-oxo-1,3-dihydro-isobenzofuran-5-yl ester (3.8 g) was mixed with acetic acid (150 ml) followed by addition of 65% nitric acid (2.5 ml). After dissolution the mixture was stirred at room temperature for 2 hours followed by removal of the acetic acid and water in vacuo. The remainder was filtered through silica gel using a mixture of toluene, ethyl acetate and methanol (8:1:1) as eluent. Appropriate fractions were collected and evaporated to dryness.

Provenance & Evidence