Potassium Nitrate → HCID 15983238, compound

Participants

Reaction Steps

(3-Chloro-5,6-dihydroxy-benzo[b]thiophen-2-yl)-morpholin-4-yl-methanone (2.0 g) from Example 28 was slurried in methanesulfonic acid (40 ml) and then potassium nitrate (0.64 g) was gradually added. The reaction mixture was stirred at room temperature and after 15 min it was poured into ice water (100 ml). The solid was filtered, washed with water (50 ml) and dried in vacuum. The resultant solid was dissolved in DMF (6.2 ml) and then ethanol (18.4 ml) was added. The product was filtered and washed with methanol (15 ml).

Provenance & Evidence