HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1881227Generated: November 3, 2026
Hydrochloric Acid → (3-Chloro-5,6-dihydroxy-benzo[b]thiophen-2-yl)-(4-hydroxy-piperidin-1-yl)-methanone
https://huagongshe.com/reaction/1881227
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Sodium Sulfite | HCID 24437 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Reactant | (3-Chloro-5,6-dimethoxy-benzo[b]thiophen-2-yl)-(4-hydroxy-piperidin-1-yl)-methanone | HCID 67094368 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (3-Chloro-5,6-dihydroxy-benzo[b]thiophen-2-yl)-(4-hydroxy-piperidin-1-yl)-methanone | HCID 67094375 | — |
Reaction Steps
Sodium iodide (1.62 g) was added to a solution of aluminum chloride (2.52 g) in acetonitrile (7 ml). After 30 minutes stirring (3-chloro-5,6-dimethoxy-benzo[b]thiophen-2-yl)-(4-hydroxy-piperidin-1-yl)-methanone (0.96 g) was added and the mixture was heated at 50° C. for 12 hours. To the mixture 2 N HCl (4 ml), Na2SO3 (0.68 g) and water were added and the mixture was heated at 60° C. for 30 minutes and then cooled to room temperature. The precipitate was filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08318785B2 |
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| Source dataset | uspto-grants-2012_11 |
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| ORD ID | ord-281b1fb5b1604a7b9435453814e9d42d |
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| Source note | uspto-grants-2012_11 |
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