1,3-Dihydro-2H-pyrrolo[2,3-c]pyridin-2-one → HCID 135936184, compound

HRID 1881334Notes

Reaction equation

HRID 1881334 reaction equation
[NH:1]1[C:5]2=[CH:6][N:7]=[CH:8][CH:9]=[C:4]2[CH2:3][C:2]1=[O:10].Cl[C:12]1[CH:17]=[CH:16][C:15]([CH2:18][N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)=[CH:14][N+:13]=1[O-]>>[O:22]1[CH2:23][CH2:24][N:19]([CH2:18][C:15]2[CH:16]=[CH:17][C:12]([C:3]3[C:4]4[C:5](=[CH:6][N:7]=[CH:8][CH:9]=4)[NH:1][C:2]=3[OH:10])=[N:13][CH:14]=2)[CH2:20][CH2:21]1

Participants

3

Reactant 2

HCID 116439331,3-Dihydro-2H-pyrrolo[2,3-c]pyridin-2-oneHCID 85873132HCID 85873132, compound

Product 1

HCID 135936184HCID 135936184, compoundYield 14%

Procedure

Prepared as described in examples 2.2 and 2.3 starting from 352 mg (2.62 mmol) of 1H-pyrrolo[2,3-c]pyridin-2(3H)-one and 500 mg (2.19 mmol of 2-chloro-5-(morpholinomethyl)pyridine 1-oxide). Amount 33 mg. Yield 14%.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-fcd67ab9ae2d4b7faaf9de702c07a27c
Source dataset
uspto-grants-2012_11
Patent number
US08318793B2

Reaction notes

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