Dichloromethane → Monatepil

HRID 188134Notes

Reaction equation

HRID 188134 reaction equation
[CH2:51]([Cl:52])[Cl:53].[CH:36]1([N:37]=[C:38]=[N:39][CH:40]2[CH2:41][CH2:42][CH2:43][CH2:44][CH2:45]2)[CH2:46][CH2:47][CH2:48][CH2:49][CH2:50]1.[F:17][c:18]1[cH:19][cH:20][c:21]([N:24]2[CH2:25][CH2:26][N:27]([CH2:30][CH2:31][CH2:32][C:33](=[O:34])[OH:35])[CH2:28][CH2:29]2)[cH:22][cH:23]1.[NH2:1][CH:2]1[c:3]2[c:4]([cH:13][cH:14][cH:15][cH:16]2)[S:5][CH2:6][c:7]2[c:8]1[cH:9][cH:10][cH:11][cH:12]2>>[NH:1]([CH:2]1[c:3]2[c:4]([cH:13][cH:14][cH:15][cH:16]2)[S:5][CH2:6][c:7]2[c:8]1[cH:9][cH:10][cH:11][cH:12]2)[C:33]([CH2:32][CH2:31][CH2:30][N:27]1[CH2:26][CH2:25][N:24]([c:21]2[cH:20][cH:19][c:18]([F:17])[cH:23][cH:22]2)[CH2:29][CH2:28]1)=[O:34]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 10868DicyclohexylcarbodiimideHCID 124891006,11-Dihydrodibenzo[b,e]thiepin-11-amineHCID 14879738HCID 14879738, compound

Product 1

HCID 60810Monatepil

Sources & evidence

ORD record
ord-5ae35319ee5544a0b2d08783e165d13c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…