HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1'-Thiocarbonyldiimidazole → 5-Isothiocyanato-indan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1'-Thiocarbonyldiimidazole | HCID 80264 | — |
| Reactant | 5-amino-2,3-dihydro-1H-inden-2-ol | HCID 21555031 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Isothiocyanato-indan-2-ol | HCID 86619701 | 69% |
Reaction Steps
5-Amino-indan-2-ol (149 mg, 1 mmol) was dissolved in CH2Cl2 (10 mL) and TCDI (thiocarbodiimidazole, 178 mg, 1 mmol) was added to the solution. The reaction mixture was stirred at room temperature for 30 min. Silica gel was added to the reaction mixture and dried. Purification of silica gel coated crude product by column chromatography (EtOAc:Hexane=3:7) afforded the title product as a white solid (132 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318790B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-8573e09a03784c55aa6bd940d12e446a |
| Source note | uspto-grants-2012_11 |