Hydrochloric Acid → HCID 178516577, compound

Participants

Reaction Conditions

Reaction Steps

To the intermediate (400 mg, 0.77 mmol) was added degassed 2N—NaOH (0.7 mL, 0.35 mmol) and the reaction mixture was stirred at 110° C. for 2 h. After cooled down to room temperature, the reaction mixture was acidified with 1N—HCl. The white precipitate was filtered and dried to give 5-(4,6-Bis-methoxymethoxy-biphenyl-3-yl)-4-naphthalen-1-yl-4H-[1,2,4]triazole-3-thiol as a white solid (250 mg, 65%). 5-(4,6-Bis-methoxymethoxy-biphenyl-3-yl)-4-naphthalen-1-yl-4H-[1,2,4]triazole-3-thiol (190 mg, 0.38 mmol) was dissolved in MeOH (7 mL) and 6N—HCl (0.5 mL) was added to the solution. The reaction mixture was heated at 50° C. for 2 h. After MeOH was removed under vacuum, the reaction mixture was extracted with EtOAc (20 mL×3). The combined organic layers were washed with water and brine and dried over MgSO4. The purification of the concentrated crude product by column chromatography (MeOH 10% in CH2Cl2) afforded the title product as white solid (120 mg, 77%).

Provenance & Evidence