Valproic Acid → 3-[4-(2-Propyl-pentanoyl)-phenyl]-acrylic acid

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Reaction Steps

This compound, a precursor to compounds 9 and 10, was synthesized from 2-propyl-pentanoic acid (0.78 mL, 4.9 mmol) and 3-(4-amino-phenyl)-acrylic acid methyl ester (0.86 g, 4.9 mmol) according to Methods a and b aforementioned. Total yield, 1.05 g (70% for 2 steps); 1 H NMR (CDCl3, 10% DMSO-d6) δ 9.49 (s, 1 H), 7.71 (d, J=8.5 Hz, 2 H), 7.55 (d, J=15.9 Hz, 1 H), 7.45 (d, J=8.4 Hz, 2 H), 6.31 (d, J=15.9 Hz, 1 H), 2.40 (m, 1 H), 1.7-1.1 (m, 8 H), 0.87 (t, 6 H).

Provenance & Evidence