Ammonia → HCID 178442465, compound

HRID 1881397Notes

Reaction equation

HRID 1881397 reaction equation
[CH3:1][C:2]([CH3:8])([CH:6]=[CH2:7])[CH2:3][CH:4]=O.[NH3:9].C1(C)C(S([CH2:19][N+:20]#[C-:21])(=O)=O)=CC=CC=1>CO>[CH3:1][C:2]([CH3:8])([CH:6]=[CH2:7])[CH2:3][C:4]1[N:9]=[CH:19][NH:20][CH:21]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 129170803,3-Dimethylpent-4-enalHCID 53627694Toluenesulfonylmethyl isocyanide

Product 1

HCID 178442465HCID 178442465, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
40 °C

Procedure

At 30 C, 3,3-dimethylpent-4-enal (126 g, 0.34 mol) was added over 20 minutes to an ambient temperature, saturated solution of ammonia in methanol (2.7 L). After stirring at 40° C. for 30 minutes, toluenesulfonylmethyl isocyanide (67 g, 0.4 mol) was added. After stirring at reflux overnight, the reaction mixture was concentrated, dissolved in ether and poured into 2N ammonium hydroxide (1500 mL) and stirred. The aqueous phase was extracted with ether. The combined organic extracts were washed with brine, dried (magnesium sulfate), filtered, and concentrated in vacuo to afford 4-(2,2-dimethylbut-3-en-1-yl)-1H-imidazole which was used in the subsequent step without further purification.

Workup

  1. stirringAfter stirring
  2. temperatureat reflux overnight
  3. concentrationthe reaction mixture was concentrated
  4. dissolutiondissolved in ether
  5. additionpoured into 2N ammonium hydroxide (1500 mL)
  6. stirringstirred
  7. extractionThe aqueous phase was extracted with ether
  8. washThe combined organic extracts were washed with brine
  9. dry with materialdried (magnesium sulfate)
  10. filtrationfiltered
  11. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-00eeae5921984a3c8b7f751307c008fd
Source dataset
uspto-grants-2012_11
Patent number
US08318767B2

Reaction notes

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