HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 4-bromo-3-fluorobenzeneacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-(4-Bromo-3-fluorophenyl)acetonitrile | HCID 11600953 | — |
| Product | Methyl 4-bromo-3-fluorobenzeneacetate | HCID 71265948 | — |
Reaction Steps
(4-bromo-3-fluorophenyl)acetonitrile (40 g, 0.18 mol) was dissolved in 120 mL methanol, and 65 mL concentrated sulfuric acid were added. After heating at reflux overnight, the reaction mixture was cooled, and poured into 600 mL water, and the product was extracted with CH2Cl2. The combined extracts were washed with 10% sodium carbonate solution, dried, and concentrated to afford methyl (4-bromo-3-fluorophenyl)acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318767B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-1f802d86fc1f404a85dc2c82c04d1206 |
| Source note | uspto-grants-2012_11 |