HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-Methoxycarbonyl-2-thiophenecarboxylic acid hydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 5-(Methoxycarbonyl)thiophene-2-carboxylic acid | HCID 818352 | — |
| Product | 5-Methoxycarbonyl-2-thiophenecarboxylic acid hydrazide | HCID 14871961 | 72% |
Reaction Steps
The known procedure disclosed in the literature (J. Heterocyclic Chem., 28, 17, (1991).) was followed using 5-methoxycarbonyl-2-thiophenecarboxylic acid synthesized in Reference Synthetic Example 38, thionyl chloride and hydrazine monohydrate to give 144 mg of the desired product as a white solid (yield 72%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318796B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-ec363db9da67441186960927654e0274 |
| Source note | uspto-grants-2012_11 |