HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 3-Acetamino-4-methoxycarbonylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 3-Amino-4-(methoxycarbonyl)benzoic acid | HCID 5235500 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-Acetamino-4-methoxycarbonylbenzoic acid | HCID 67050201 | 89.4% |
Reaction Steps
Acetic anhydride (1.89 mL, 20 mmol) was added to a suspension of 3-amino-4-methoxycarbonylbenzoic acid (1.95 g, 10 mmol) in acetic acid (10 mL), and the mixture was heated with reflux for 6 hours. After cooling, the precipitated solid was filtered to obtain 2.12 g of the desired product as a colorless solid (yield 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318796B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-6e4a427509804e0a95c77235ca390e8e |
| Source note | uspto-grants-2012_11 |