反应详情

温度

100 °C

2-Oxopropanal methylhydrazone (8.540 mmol, 855 mg) synthesized in Reference Synthetic Example 1 and (4-trifluoromethylphenyl)(oxo)acetaldehyde (6.432 mmol, 1.3 g) synthesized in Reference Synthetic Example 7 were dissolved in acetic acid (30 mL) and stirred at 100° C. for about 5 hours. Then, the solvent was evaporated, and the residue was dried by means of a vacuum pump and purified by silica gel column chromatography (n-hexane/AcOEt=2/1, and 4/1) to give the desired product as an orange solid (157.3 mg, yield 8.6%).

1. customsynthesized in Reference Synthetic Example 7
2. customThen, the solvent was evaporated
3. customthe residue was dried by means of a vacuum pump
4. custompurified by silica gel column chromatography (n-hexane/AcOEt=2/1, and 4/1)