Hydrochloric Acid → HCID 72359957, compound

Participants

Reaction Steps

Methyl 4-[(2-{1-[5-(4-t-butylphenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate (50 mg, 0.11 mmol) synthesized in Synthetic Example 35 was dissolved in methanol (1.1 mL) and stirred with 1 M aqueous sodium hydroxide (0.55 mL, 0.55 mmol) at 45° C. for 1.5 hours. After the stirring, 1 M hydrochloric acid (0.55 mL, 0.55 mmol) was added, and the precipitated pale yellow solid was recovered by filtration. The resulting solid was purified by silica gel chromatography (chloroform:methanol=9:1). The resulting solid was stirred with chloroform at room temperature and recovered by filtration to give the desired product as a pale yellow solid (11 mg, yield 23%).

Provenance & Evidence