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2-(3,4-Dichlorophenyl)-3-hydroxy-4-(methylcarbonyl)thiophene → Methyl 2-nitro-4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(3,4-Dichlorophenyl)-3-hydroxy-4-(methylcarbonyl)thiophene | HCID 44207288 | — |
| 反応物 | 4-Methoxycarbonyl-3-nitrobenzhydrazide | HCID 66986356 | — |
| 生成物 | Methyl 2-nitro-4-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxy-3-thienyl]ethylidene}hydrazino)carbonyl]benzoate | HCID 72360084 | — |
反応手順
Using 2-(3,4-dichlorophenyl)-3-hydroxy-4-methylcarbonylthiophene (100 mg, 0.35 mmol) and methyl 2-nitro-4-hydrazinocarbonylbenzoate (93 mg, 0.39 mmol) as the starting materials, the desired product was obtained in the same manner as in Synthetic Example 65 as a yellow solid (147 mg, yield 83%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08318796B2 |
| 出典データセット | uspto-grants-2012_11 |
| ORD ID | ord-de6f79af1b57426b935a6e951322b54a |
| 出典メモ | uspto-grants-2012_11 |