Trifluoroacetic acid → 2-[[(2S)-1-[(4-Methoxy-2,6-dimethyl-phenyl)sulfonyl]-piperidin-2-yl]-methoxy]-1-[4-pyridin-4-yl-4-(2-pyrrolidin-1-yl-ethoxy)-piperidin-1-yl]-ethanone

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Reaction Steps

DIPEA (4 eq.), EDCl (1.2 eq.) and HOBt (1 eq.) were added to a solution of (S)-2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)acetic acid [acid D] (0.65 mmol) in methylene chloride (5 ml). tert-Butyl 4-(pyridin-4-yl)-4-(2-(pyrrolidin-1-yl)ethoxy)piperidine-1-carboxylate [amine J] (0.78 mmol) [Boc-deprotected in the presence of TFA (10-13 eq.) in methylene chloride (see e.g. stage (iii)/amine H)] and DIPEA (2 eq.) were added dropwise in methylene chloride (3 ml) to the reaction mixture, while cooling with ice, and the mixture was stirred at room temperature overnight. The reaction mixture was diluted with methylene chloride and washed with saturated ammonium chloride solution, saturated sodium chloride solution, saturated sodium bicarbonate solution and finally with sat. sodium chloride solution again. The organic phase was dried over sodium sulfate and concentrated to dryness on a rotary evaporator. The crude product was purified by means of column chromatography (silica gel, methanol/methylene chloride) to obtain the desired product. Yield: 36%. MS, Rt=2.6 min, m/z=629.4 [MH]+

Provenance & Evidence